Growing Spirulina is one of the most promising opportunities in commercial microalgae production, offering exceptional nutritional value and robust market demand across multiple industries. Lab managers and bioprocess engineers seeking to optimize Spirulina production must understand the complex interplay between cultivation parameters, system design, and operational efficiency that determines commercial success. Recent advances in algae bioreactor technology have revolutionized Spirulina cultivation, enabling consistent, high-quality production whilst minimizing operational challenges that historically plagued commercial operations. LGEM’s extensive experience with uninterrupted Spirulina cultivation over two years demonstrates the potential for reliable, scalable production when proper systems and protocols are implemented. Understanding